The Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized Trial
Read full paper →- Authors
- Trevor J. Orchard, Marinella Temprosa, Ronald Goldberg, Steven M. Haffner, Robert E. Ratner, Santica M. Marcovina, Sarah Fowler
- Journal
- Annals of Internal Medicine
- Year
- 2005
- Citations
- 938
TL;DR
This study found that an intensive lifestyle intervention (targeting 7% weight loss and 150 minutes of exercise per week) reduced the risk of developing metabolic syndrome by 41%, and metformin (850 mg twice daily) reduced it by 17% over 3.2 years in people at